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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 16, Issue 1, Aug 2015 pp 163-168

Research Article

Evaluation of two different doses of Dexmedetomidine in attenuation of pressor response during laryngoscopy and intubation

Shilpa Sale1, Shama Shikalgar2, Prashant Lomate3, Ganesh Kumbhar4, Vikas Kumar5

1,5PG Student, 2Professor, 3Assistant Professor, 4Lecturer, Department of Anaesthesia, BVDU Medical College and Hospital, Sangli, Maharashtra, INDIA.

Introduction: Pressor response to laryngoscopy and intubation have been associated with sympathetic and parasympathetic responses like Hypertension, Tachycardia due to increased plasma catecholamine concentrations. Premedication with Dexmedetomidine attenuates pressor response to laryngoscopy and intubation. Aims and Objective: to evaluate and compare effects of 2 different doses of Dexmedetomidine 1mcg/kg and 0.6mcg/kg in attenuating pressor response to laryngoscopy and intubation. Methods: 60 patients aged 18-50 years of either sex of ASA grade I and II scheduled for elective surgery were randomly divided into 2 groups. All patients were uniformly premedicated, 10 mins before induction. Group A received Inj Dexmedetomidine 1mcg/kg and Group B received Inj Dexmedetomidine 0.6mcg/kg iv. After induction with Thiopentone and succinylcholine, laryngoscopy and intubation was done. HR, SBP, DBP were recorded for both groups before premedication, 10min after premedication and 1min, 2min, 3min, 5min, 7min,10min after intubation. Data was analyzed and compared with paired t test. Results: HR and BP levels were lower at 10min after premedication and 5min after intubation than baseline levels in both groups. But in Dexmedetomidine 1mcg/kg group amount of increase in HR, SBP, DBP were lower compared to 0.6 mcg/kg. Conclusion: Dexmedetomidine 1mcg/kg is more effective than 0.6 mcg/kg in attenuating pressor response to laryngoscopy and intubation and provides more stable hemodynamic profile.