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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 16, Issue 1, Aug 2015 pp 20-21
Research Article
Screening of Glucose-6-Phosphate Dehydrogenase deficiency in Neonates
Raviraj Naik1, Sarita Dakhure2, Rittu Chandel3, Leela Abichandani4
1,2Assistant Professor, Department of Biochemistry, IIMSR, Warudi, Jalna, Maharashtra, INDIA.
3Assistant Professor, Department of Biochemistry, Dr. SGGS Medical College, Nanded, Maharashtra, INDIA.
4Professor and Head, Department of Biochemistry, Grant Medical College, Mumbai, Maharashtra, INDIA.
Abstract
Introduction: Glucose – 6 – phosphate dehydrogenase (G-6-PD) is an enzyme that participates in the first step of Hexose monophosphate pathway of glucose metabolism. Deficiency of this enzyme is most common genetic disorder in India. Its deficiency causes hemolysis which eventually lead to acute haemolytic anemia and neonatal jaundice. The hemolysis in these deficient patients are triggered by bacterial, viral infections, drugs like aspirin and chloroquine, foods like fava beans Period from after birth to first 4 weeks is the neonatal period and the child is called a neonate. There is no cure for G-6-PD.Early detection and prevention of hemolytic episodes by avoiding the triggers is the only cure for this deficiency. Aim: To screen the neonates for glucose -6-Phosphate dehydrogenase deficiency so as to prevent the morbidity and mortality occurring due to this deficiency. Material and Methods: One Thousand neonatal blood sample were obtained from the Labour room, of the civil Hospital of vasai. The samples were analysed by Dye Decolourization method. Results: Of the 1000 samples, 10 was found to be G-6- PD deficient and 20 were found to be G-6-PD deficiency carriers. Conclusion: G-6-PD deficiency is common in Adivasi Population.G-6-PD deficiency testing should be done as a screening procedure at least in Adivasi residing areas as early diagnosis and prevention is the only way of treating this deficiency disorder and avoiding its complications.
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