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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 16, Issue 2, Sept 2015 pp 233-235
Gastric antiulcer activity of melatonin and its potentiation by pyridoxine in pylorus ligated rats
G Rajaram1, P Sugirda2, R Lenin3
1Professor, 2,3Assistant Professor, Department of Pharmacology, Government Viluppuram Medical College, Viluppuram-605 601, Tamil Nadu, INDIA.
Aim: To study the gastric antiulcer activity of melatonin and its potentiation by pyridoxine in pylorus ligated rats. Methods: Eighteen healthy albino rats were divided into three groups of six each. Group A received normal saline, Group B received melatonin (15mg/kg/day) and Group C was given melatonin and Pyridoxine (0.3mg/kg/day). Drug treatment was continued orally for 2 wks and at the end animals were starved for 36 hours. pylorus ligation was carried out under ether anesthesia. After 18 hours of pylorus ligation, all the animals were sacrificed and their stomachs were removed. Results: The volume of secretion, PH and ulcer index was noted in all the three groups. Melatonin showed reduction in acid secretion, ulcer index and rise in PH and its effect was potentiated by pyridoxine. Conclusion: It appears that the anti ulcer activity of melatonin may be due to its anti-oxidant property. The protective effect of melatonin has been further potentiated by pyridoxine, which may enhance the synthesis of endogenous melatonin.