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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 16, Issue 2, Sept 2015 pp 339-343
Fasting lipid profile, fasting blood sugar and anthropometric parameters in Human Immunodeficiency Virus infected patients not initiated on antiretrovirals
Arunraj C N*, Sundeep S**
*,**Associate Professor, Department of General Medicine, Travancore Medical College, Kollam-691589, Kerala, INDIA.
Aims: 1. To evaluate the fasting lipid profile and fasting blood sugar in HIV patients who are not initiated on antiretroviral drugs and compare with that of healthy controls. 2. To assess the anthropometric parameters of HIV patients who are not initiated on antiretroviral drugs and compare with that of healthy controls. Methods: HIV positive patients attending Internal Medicine and Infectious Diseases departments in a tertiary care hospital in South India satisfying the inclusion criteria were included in the study as cases. Healthy subjects in the age group 20-40 years were taken as controls. The study was conducted in forty cases and forty controls. Results: Analysis of anthropometric parameters showed a mean waist circumference of 81 cm in cases, compared to 76cm in controls with a difference of 5 cm (P<0.01). The mean waist-hip ratio for cases and controls were 0.86 and 0.83 respectively with a difference of 0.03. (P<0.01). The mean body mass index in cases and controls were 20.7 and 23 kg/m2 with a difference of 2.3 kg/m2 (p<0.01). The mean total cholesterol, triglycerides, LDL-C, HDL-C, VLDL-C, FBS were 179, 131.1, 107.2, 45.7, 26.2,88.9 mg/dL in control compared to 160.3, 222.6, 77.1, 38.9, 44.2, 92 mg/dL respectively in cases(P<0.001). Analysis of fasting lipid profile showed a decreased in total, LDL and HDL cholesterol and increase in TG and VLDL-C in HIV positive cases compared to controls. Comparison of FBS between control and cases showed a difference in mean FBS of 3 mg/dL which was not statistically significant. Conclusion: Significant metabolic and morphological alterations occur in HIV infected, treatment-naïve patients. There is a substantial decrease in serum total cholesterol, HDL-C, LDL-C and an increase in TG and VLDL-C in HIV infected. There is increased incidence of impaired fasting blood glucose in advanced HIV. There is significant alteration in body morphology in HIV as noted by increased waist circumference and waist-hip ratio with possible fat redistribution causing central obesity and peripheral lipoatrophy.