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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 16, Issue 2, Sept 2015 pp 348-350
A comparative study between on dansetron and dosalesetron for prevention of post operative nausea and vomiting
C Badri Narayan
Assistant Professor, Department of Anaesthesology and Critical Care, Gandhi Medical College, Padmarao Nager, Secunderabad, Hyderabad, Telangana, INDIA.
Introduction: Post operative nausea and vomiting (PONVS) is the most common complication of surgery and anaesthesia, leading to adverse consequences including patient dissatisfaction, unexpected hospital admission, and delayed recovery. The present study is done to compare the efficacy of a single dose of Ondansetron Versus Dosalesetron for preventing post operativenausea and vomiting (PONY) in patients undergoing abdominal surgery under general anaesthesia within 24 hrs post operatively. Aims and Objectives: To compare the incidence of post-operative nausea and vomiting in Ondansetron and group of patients and to compare the severity of nausea in Ondansetron and Dosalesetron group of patients and to compare the need for rescue medications in Ondansetron and Dosalesetron groups of patients undergoing abdominal surgery under general anesthesia within 24 hours Methodology: The present one year prospective randomized clinical trial was conducted in the department of anaesthesiology during the period of 2013 - 2014 on 90 patients undergoing abdominal surgeries under GA. The patients were randomly allocated into two groups, Group A (Ondansetron group) and Group B (Dosalesetron) of 45 each by computer generated randomization. Results: It was observed that incidence of nausea and vomiting in Ondansetron and Dosalesetron was not significantly different from each other (33.33% and 26.67% with P>0.05) and (35.56% and 31.11% with P>0.05) respectively. Also the severity of nausea was significantly lesser in Dosalesetron group as compared to Ondansetron group (1.47±3.10 Vs ±3.85 respectively) during 0-24 hrs. (P <0.05) It was observed that the need of rescue medication was lower in Dosalesetron group as compared to Ondansetron group (15.56% vs 40% respectively) during 0-24 hrs. The difference was statistically significant. (P < 0.05). Conclusion: From the above study we conclude that Dosalesetron is more cost-effective than Ondansetron as less amount of rescue medicine are required, in preventing in preventing post operative nausea and vomiting in patients undergoing abdominal surgery under anaesthesiawithn 24 hrs post operatively.