Official Journals By StatPerson Publication


Abstract Introduction: Ingestion of corrosive substances remains an important public health issue in Western countries despite education and regulatory efforts to reduce its occurrence. These injuries are still increasing in developing countries, related to the social, economic, and educational variables and mainly to a lack of prevention, Clinical presentation of corrosive injuries in the upper gastrointestinal tract depends on the physical state, type and quantity of the corrosive substance There were several reports that intramucosal injection of Mitomycin-C, a chemotherapeutic agent with DNA cross linking activity, was helpful to prevent strictures. Aims and Objectives: To study the effect of Mitomycin - C on corrosive stricture of upper GI tract (Oesophagus). Result: In the Mitomycin-C group there was considerable reduction in the number of dilatation (No. of dilatation measured during the 1 year studied) as compared with the Non - Mitomycin - C group. The Dysphagia Index improvement in the Mitomycin - C group is significantly high, compared to the Non - Mitomycin - C group. The average length of stricture in the Mitomycin - C group and non Mitomycin-C was not significantly different from each other. Conclusion: As Mitomycin-c group there was considerable reduction in the number of dilatation, as the Dysphagia Index improved in the Mitomycin - C group so definitely this drug is benefical in the management of post caustic injury in upper gastrointestinal tract but the more clinical trials are needed to establish the role in stricture prevention.

Keywords: Caustic Injuiry, Mitomycin-C, Oesophageal strictures.


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