Official Journals By StatPerson Publication


Abstract Introduction: Guillain-Barre Syndrome (GBS) has an incidence of 0.4 to 1.9 per 100,000 populations. GBS can occur at any age. The male to female ratio is 3:2. It is characterized by an acute onset, relatively symmetric, predominantly motor, flaccid, areflexic paralysis which evolves over a period of up to 4 weeks. History of antecedent viral infection, vaccination or surgery may be obtained in 50 to 70% of cases. The optimistic view of complete recovery in majority of patients with GBS may not be true and patients with severe GBS are often left with significant residual deficits. Aims and Objectives: To study the various factors affecting outcome of Guillain-Barre Syndrome. Methodology: This is a retrospective study. All patients who were diagnosed as GBS fulfilling the diagnostic criteria as modified by Asbury, admitted into the paediatric wards of Bharati Hospital during a period of 24 months were included in this study. During the study period 31 patients who fulfilled the diagnostic criteria were identified and included in the study. A detailed history with particular attention to the date of onset of neuropathic symptoms and the tempo of the ensuing functional disability and time taken to reach clinical nadir was elicited. Any significant past history and a history of any preceding event within a period of one month prior to onset of symptoms was noted. Results: In this study mortality of the GBS patients found to be 6.66%. The factors significantly associated with the outcomes like Death or Partial Recovery Were Age ≥ 10 yrs. (χ2 = 11.82, p<0.00058),Male Sex (χ2 = 2.694, p<0.05), History of Fever (χ2= 7.42, p<0.0064), History of Cranial nerve Palsy (χ2= 7.42, p<0.0064), History of Respiratory Distress (χ2= 4.310,p<0.05), Treatment Received (IVIG) (χ2= 6.17, p<0.01.). While power of the muscle during illness was not any significant co-relation with the Outcome (χ2= 6.17, p<0.01). Conclusion: Various factors like Age Sex, History of Fever, History of Cranial nerve Palsy, History of Respiratory Distress etc. should be considered for the management and better recovery the patients.

Keywords: Guillain Barre Syndrome (GBS), Intravenous Immunoglobulin (IVIG).


STATPERSON PUBLISHING GROUP | Aurangabad | Maharashtra |2016 | INDIA
© Copyright 2016 Statperson Publishing Corporation. a division of Statperson Consultancy.
All Rights Reserved.