Abstract  Background: The impact of psoriasis on quality of life of the individual may be determined by various factors such as gender, age of onset and type of the disease. No study of various factors of psoriasis determining the quality of life had been carried out in Mauritius. Objective: Aim was to study the impact of clinical and epidemiological features of psoriasis on the quality of life of the psoriatic. Methodology: The study was carried out in the Outpatient department of a regional general government hospital in Mauritius. It was a cross sectional study of consecutive 55 patients of psoriasis. The clinical features of psoriasis were correlated to a quantitatively assessed impact of psoriasis on the quality of life. The data was analyzed using SPSS 22 (Statistical Package for the Social Sciences) software. Results: Out of a total of 55 patients of psoriasis 36 (65.5%) patients were men and 19 (34.5%) women; Association between gender and the Psoriasis Disability Index (PDI) score was statistically significant (p value=0.024). Larger percentage of female patients was seen with greater PDI score. PDI was significantly dependent on stress (p value = 0.003). The patients with stress had a PDI score > 20. Involvement of the Total Body Surface Area (TBSA) less than 10% was observed in 37 (67.3%) and >10% TBSA in 18 (32.7%); 16 (83.3%) patients with involvement of TBSA >10% had PDI score >20. Psoriatic arthritis was observed in 14/55 (24.5%) patients and 13/14 (92.8%) of these patients had PDI score > 20. Conclusion: There was a significant association between the gender, stress, severity of the disease, psoriatic arthritis and the total PDI score. The disability due to psoriasis was more in females, when a larger Total Body Surface Area was affected and when joints were involved. Key words: Quality of Life, Psoriasis Disability Index (PDI) score, Total Body Surface Area (TBSA), Psoriatic arthritis.