Abstract Introduction: Long time known that the close relationship between the development of skin disease with psychological factors. In fact an estimated over 75 percent of patients with skin diseases are also affected to some psychological problems. Certain psychosomatic disorders are associated with severe itching and other skin diseases and in common mental disorders found frequently. Moreover, the onset and course of dermatologic disorders may be significantly influenced by stress. Aims and Objective: To study Prevalence and associated factors of Eczema and Infection at Psychiatry Inpatient Department Methodology: This was a cross-sectional, descriptive study of the patients admitted to psychiatry inpatients department at tertiary care hospital during the Jan2014 to Jan 2015 one year study, all the patients admitted to inpatients department were studied, Patients skin problems like Eczema or any skin infection were studied it found that out 360 psychiatric 100 patients were having skin problems. The patient’s related information was collected by semi-structured questionnaire. Statistical analysis done by Graph Pad prism 5 for the calculation of Chi-square test. Result: Overall prevalence of Eczema and Skin Infection was found to be 27.78% in psychiatrically ill patients. The Eczema and Skin Infection were more common in the age group of psychiatrically ill patients above 50 yrs. i.e. in 51-60 (37.50%);61-70 (36.70%);>70 (44.70%).The presence of Eczema and Skin Infection was compared in between age <50 yrs. and > 50 was compared , the observed difference was statistically highly significant. (p<0.001X²= 42.12). Presence of Eczema and infection in Males and female was comparable to each other; the difference was not statistically significant (p>0.05; X²= 3.408). Presence of Eczema and infection in Rural and Urban similar, the difference was not statistically significant (p>0.05; X²=2.25). It is found that Eczema and infection were significantly higher in the Group of patients having psychiatric illness like Disorders due to psychoactive Substance use, Schizophrenia and Delusional disorders than the patients having Neurotic, stress-related and somatoform disorder, Organic Mental Disorders, Mood disorders, Disorder of Childhood and adolescents (p<0.0001 ;X²=31.19). Conclusion: Eczema and infection were found to be more common with increasing age in psychiatrically ill patients and also; significantly higher in the Group of patients having psychiatric illness like Disorders due to psychoactive Substance use, Schizophrenia and Delusional disorders than the patients having Neurotic, stress-related and somatoform disorder, Organic Mental Disorders, Mood disorders, Disorder of Childhood and adolescents.

                        Keywords: Eczema, Skin Infection, Psychiatric illness.