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Abstract    Aim: The aim of this study is to evaluate the analgesic activity of atorvastatin in tail clip model of rat. Methods and Material: Analgesic activity of atorvastatin 3mg/kg and 8mg/kg were assessed in in tail clip model of rat where they were compared with control and ibuprofen group. Results: In tail clip method of rats, Atorvastatin 8 mg/kg group showed significant analgesic activity as compared with control group on day 3 and 6. However, atorvastatin 3 mg/kg group did not show any analgesic effect. Analgesic activity of both group of atorvastatin showed improvement as the study progressed from day 3 to day 6. Conclusion: The result of this study if substantiated by further experimental and clinical research suggest that atorvastatin may play important role in treating painful condition like osteoarthritis and rheumatoid arthritis specially when there is coexisting hypercholesterolemia.

Key words: tail clip, analgesic.



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