Abstract    One of the most debilitating types of infection is osteomyelitis; the infection of bone and its marrow. Most common cause of osteomyelitis is Staphylococcus Aureus, but in certain cases other organisms can be isolated. Proteus organisms are rare causes of osteomyelitis; may be seen in HIV positive cases. A 20 year old male, sickle cell positive, HIV negative patient came to our outpatient department with complaint of discharging sinus at upper third of tibia left side, since 4-5 months. Sequestrectomy was done with sinuvectomy and drainage of pus. Pus was sent for culture and sensitivity reporting; which showed Proteus Mirabilis growth. Patient was treated with Linezolid and ofloxacin both intravenous and oral. Proteus Mirabilis causing osteomyelitis is a very rare phenomenon, but should be suspected in HIV seropositive cases. It should be suspected even in HIV seronegative patients not responding to long term use of antibiotics. Surgery is the mainstay of treatment. Antibiotics should be started only after doing the culture and sensitivity reporting.

                        Keywords:

.