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Abstract    Aim: The aim of this study is to evaluate the anti-inflammatory activity of atorvastatin in carrageenan induced rat paw oedema. Methods and Material: Anti-inflammatory activity of atorvastatin 3mg/kg and 8mg/kg were assessed in carrageenan induced paw edema in rats (n=6) where they were compared with control and ibuprofen group. Results: In carrageenan induced paw edema in rats, both groups of atorvastin showed anti-inflammatory effect (p<0.01). Anti-inflammatory activity of atorvastatin 8mg/kg was comparable to ibuprofen. Conclusions: The result of this study if substantiated by further experimental and clinical research suggest that atorvastatin may play important role in inflammatory disorders, especially when there is coexisting hyperlipidemia.

Keywords: carrageenan, paw oedema, anti-inflammatory.



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