Abstract          Introduction: Increase in heart rate and blood pressure is well documented sequelae of direct laryngoscopy and endotracheal intubation in normotensive individuals. Direct laryngoscopy and endotracheal intubation frequently induces a cardiovascular stress response characterized by hypertension, tachycardia due to reflex sympathetic stimulation which in turn leads to increased plasma catecholamine concentration Aims and Objectives: To study Lignocaine in attenuation of cardiovascular response to Laryngoscopy and Endotracheal intubation Materials and Methods: The study was approved by the Ethics Committee of Kidwai Memorial Institute of Oncology, Bangalore and all patients gave valid written informed consent. One Sixty inpatients, 20 – 60 years of age, of either sex undergoing elective surgical procedures at Kidwai Memorial Institute of Oncology, Bangalore requiring general anaesthesia with endotracheal intubation were selected randomly. The study was conducted in the Department Of Anaesthesia and Pain Relief, Kidwai Memorial Institute of Oncology, Bangalore for a period of one year 01-01-2013 to 01-01-2014. Descriptive and inferential statistical analysis has been carried out in the present study. Results on continuous measurements are presented on Mean ± SD (Min-Max) and results on categorical measurements are presented in Number (%). Significance is assessed at 5 % level of significance. Result: The increase in mean HR immediately after intubation, at 1and 5 minutes after intubation compared to basal HR was statistically significant(p<0.001).The decrease in mean SBP observed at 1, 3, 5 and 10 minutes after intubation when compared with basal SBP was statistically significant (p<0.05). The decrease in mean DBP observed at 3, 5 and 10 minutes after intubation when compared with basal DBP was statistically significant (p<0.05). The decrease in MAP observed at 3, 5 and 10 minutes after intubation when compared with basal MAP was statistically highly significant (p<0.01). Conclusion: Lignocaine significantly attenuates the cardiovascular responses to laryngoscopy and intubation.

Keywords: Lignocaine, cardiovascular response to Laryngoscopy and Endotracheal intubation.