Abstract          Introduction: Direct laryngoscopy and endotracheal intubation frequently induces a cardiovascular stress response characterized by hypertension, tachycardia due to reflex sympathetic stimulation which in turn leads to increased plasma catecholamine concentration. Increase in heart rate and blood pressure is well documented sequelae of direct laryngoscopy and endotracheal intubation in normotensive individuals. Aims and Objectives: To Study Variations in Sympathetic Response to Laryngoscopy and Intubation Observed With Intravenous Magnesium Sulphate, Esmolol and Lignocaine. Materials and Methods: The study was approved by the Ethics Committee of Kidwai Memorial Institute of Oncology, Bangalore and all patients gave valid written informed consent. One Sixty inpatients, 20 – 60 years of age, of either sex undergoing elective surgical procedures at Kidwai Memorial Institute of Oncology, Bangalore requiring general anaesthesia with endotracheal intubation were selected randomly. The study was conducted in the Department Of Anaesthesia and Pain Relief, Kidwai Memorial Institute of Oncology, Bangalore for a period of one year 01-01-2013 to 01-01-2014. Descriptive and inferential statistical analysis has been carried out in the present study. Results on continuous measurements are presented on Mean ± SD (Min-Max) and results on categorical measurements are presented in Number (%). Significance is assessed at 5 % level of significance. Result: Statistical evaluation between the groups showed that the decrease in mean HR observed in group E was statistically significant when compared to decrease in mean HR in the group L, M (p<0.001) at 1min after drug admin, immediately after intubation and 1, 3, 5 and10 minutes following intubation ; also mean SBP observed in group L was statistically highly significant when compared to decrease in mean SBP in the group E, M (p<0.05) immediately after intubation and 1, 3, 5 and10 minutes following intubation. The decrease in mean SBP at 10min after intubation was also maximum in group Lin comparison to the baseline value and the decrease in mean DBP observed in group E was statistically significant when compared to decrease in mean DBP in the group L, M (p<0.05) immediately after intubation and 1 minute following intubation. The decrease in mean DBP observed in group L was statistically significant when compared to decrease in mean SBP in the group E, M (p<0.05) at 3 and 5 minutes following intubation. The decrease in mean DBP at 10min after intubation was not significant in any of the groups in comparison to the baseline value. Conclusion: Esmolol is more effective when compared to both lignocaine and magnesium sulphate in attenuating the cardiovascular response i.e. Sympathetic Responseto laryngoscopy and intubation.