Abstract Introduction: Anxiety in children undergoing anaesthesia and surgery is characterized by feelings of apprehension, tension, and nervousness. Separation of the child from parents and induction of anaesthesia have been found to be the most stressful period during the surgical/anaesthesia experience Aims and Objectives: To Compare Study of Oral Dexmedetomidine and Oral Midazolam With Respect To Sedation and Mask Acceptance as Premedication in Children. Methodology: This prospective randomized double blinded, study was conducted in the Department of Anaesthesiology at Government Stanley Medical College and Hospital between April 2013 and November 2013. Chi-square test was used for statistical analysis Patients were divided in the Dexmedetomidine, Midazolam group randomly Result: There is no statistical difference between the two groups at 10 and 20 minutes. At the end of 30 minutes, 22 patients achieved a score of 3 in Group D, compared to 56 patients in Group M. Only 4 patients in Group M still had a score of 1. Whereas 20 patients in group D still had a score of 1.This result is statistically significant At the end of 40 min, 100% of the patients achieved a score of 3 in group M whereas only 80% achieved it in Group D this is statistically significant. At 50 min Chi square 5.217, P < 0.02. At 60 min Chi square 0.0084, P value - 1, the result is Not Statistically Significant. The mask acceptance score between group M and group D are comparable with a p value of. 093 Group D showed an excellent mask acceptance (score of 1)of 60% with 43.30% acceptance in group M, 53.30% of Group M and 40% of Group D showed a good mask acceptance. Conclusion: The Sedation Score at 30, 40 and 50 was better in Midazolam Group as Compared. To Dexmedetomidine while mask acceptance score was comparable to each other.

Keywords: Dexmedetomidine, Midazolam, Sedation Score, Mask Acceptance Score.