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Abstract This study was done to analyze the various biochemical parameters that aid the evaluation of a case of alcoholic liver cirrhosis. In a setting of Alcoholic Liver Disease (ALD), patients with liver cirrhosis can progress to end stage liver disease at a faster pace. Numerous parameters are available to diagnose and assess the progression of cirrhosis to end stage liver disease. The aim of this study is to assess few of these biochemical parameters which can help us to identify liver cirrhosis in an alcoholic liver disease. The parameters in this study included serum Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Gamma Glutamyl Transferase (GGT), Albumin, Total Bilirubin and Prothrombin Time-International Normalized Ratio (PT-INR). We assessed a total of 40 patients with alcoholic liver disease in this study, to ascertain the pattern of variation in the above mentioned biochemical parameters with the onset and progression of liver cirrhosis. After the detailed review and analysis of the various biochemical investigations in these subjects we found that AST/ALT ratio was more than 2:1 in 75% of our patients, serum albumin was less than 2.5 in 83.7% and GGT was elevated than normal in 67.5%. Total bilirubin was elevated (i.e., more than 1.2) in 77.5% and PT-INR value more than1.5 was noted in 72.5% of our cases. These results were corresponding with the expected laboratory results in alcoholic liver cirrhosis thereby establishing their role in predicting the advancement of early alcoholic liver disease to cirrhosis and end stage liver disease.

Keywords: liver cirrhosis.






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