Abstract Introduction: The major responsibility of an anaesthesiologist is the management of airway to provide adequate ventilation to the patient by securing airway during general anaesthesia. As such, no anaesthesia is safe unless diligent efforts are devoted to maintain an intact functional airway. Aims and Objectives: To Study of Cardiovascular Response to Laryngoscopy and Tracheal Intubation Following Intravenous Lignocaine with Lignocaine Nebulization. Methodology: It was a Comparative, undertaken in Victoria hospital and Bowring and Lady Curzon hospitals, Bangalore during November 2008 to 2010. Ethical clearance was obtained for the study. The study was conducted on 90 ASA grade I and II patients in the age group of 18 to 45 years of either sex scheduled for elective surgeries done under general anaesthesia. Patients were allocated into three groups with the sample size of 30 each.Group C (n=30) received no drug, as control. Group I (n=30) received 2% Lignocaine 2mg/kg slow intravenous. Group N (n=30) received 2% nebulization of Lignocaine 2mg/kg. Descriptive statistical analysis has been carried out in the present study. Analysis of variance (ANOVA) has been used to find the significance of study parameters between three or more groups of patients, Chi-square/ Fisher Exact test has been used to find the significance of study parameters on categorical scale between two or more groups. Result: The maximum rise in heart rate was noted at 1 min following intubation in all the three groups. The mean rise in Heart rate at 1 minute in control group was 23.4bpm compared to 18bpm and 24.86bpm in group I and group N respectively. The maximum rise in Systolic blood pressure was noted at 1 min following intubation in all the three groups. The mean rise in Systolic blood pressure in control group was 42.6mm Hg compared to 17.54mm Hg and 32.26mm Hg in group I and group N respectively. The maximum rise in Diastolic blood pressure was noted at 1 min following intubation in all the three groups. The mean rise in Diastolic blood pressure in control group was 25.36 mm Hg compared to 13.84 mm Hg and 24.83 mm Hg in group I and group N respectively. The maximum rise in Mean arterial blood pressure was noted at 1 min following intubation in all the three groups. The mean rise in Mean arterial blood pressure in control group was 29.44 mm Hg compared to 16.1 mm Hg and 27.3 mm Hg in group I and group N respectively. Conclusion: In our study though nebulization was not effective in blunting the haemodynamic responses to laryngoscopy and intubation, it is still a safe and a simple technique to be used.

Key Words: Cardiovascular Response to Laryngoscopy and Tracheal Intubation, Intravenous Lignocaine, Lignocaine Nebulization.