Abstract Introduction: Soft tissue can be defined as nonepithelialextraskeletal tissue of the body. Soft tissue tumors are a highly heterogeneous group of tumors that are classified on histogenetic basis according to the adult tissue they resemble. The large majority of soft tissue tumors are benign with a very high cure rate after surgical excision Aims and Objectives: To study Spectrum of Soft Tissue Tumors in Tertiary Cancer Centre. Material and Method: All soft tissue tumors diagnosed between January 2006 to June 2011 were retrieved from the surgical pathology files of the Department of pathology, Sri Ramachandra Medical College and Research Institute. A total of 513 cases were collected and reviewed .Out these cases benign, intermediate and malignant cases were identified. The malignant cases were selected for this study. Hematoxylin and eosin (H&E) stained sections were reviewed along with the grading of the tumours according to FNCLCC grading system. Result: Out of the 513 cases 297(58%) were males and 216(42%) were females. The age of patients in our study varied between 4 months to 82 years . Out of 513 cases of soft tissue tumours 74% were benign, 8% intermediate and 18% malignant. Histological grading was done on soft tissue sarcomas according to FNCLCC grading system. There were 23 cases in grade 1, 13 cases in grade 2 and 27 cases in grade 3. In Sarcomas the predominant site was the lower extremity with 33 cases followed by retro peritoneum 11cases and the upper extremity with 10 cases. There are 261 cases of adipocytic, 52 cases of vascular and 21 cases of fibrohistiocyticorigin. There are 261 cases of adipocytic, 52 cases of vascular and 21 cases of fibro histiocyticorigin . The predominant origin of intermediate tumours in our study were from fibroblastic (74%), Fibrohistiocytic (19%) and adipocytic (7%). Based on the origin of tumors, the predominant group belonged to the uncertain differentiation with 27%, fibroblastic origin 19% and 14% smooth muscle origin. Conclusion: Soft tissue tumours occur mostly within age group of 31 to 40 years with a slight male predominance Lower extremities are the most common site of the sarcomas Histological origin of various malignant the predominant group belonged to the uncertain differentiation with 27%, fibroblastic origin 19% and 14% smooth muscle origin

Key Words: Spectrum of Soft Tissue Tumors, FNCLCC (French Federation of Cancer Centers Sarcoma Group) System, Sarcoma.