Abstract      Serum CRP (C-reactive protein), serum protein and urine protein were done in 50 patients of Diabetes Mellitus (DM) without Chronic renal failure (CRF), 50 patients of DM with CRF on Dialysis and 50 age and sex matched healthy control. Mean level of serum CRP and urine protein were significantly increased in DM without CRF group as compared to control, and DM with CRF on dialysis group as compared to control and DM without CRF group. While mean level of serum protein was significantly decreased in DM with CRF on Dialysis group as compared to control and DM without CRF group. Thus higher value of CRP and urine protein with lower serum protein suggest un-favourable condition aggravated by renal insufficiency and DM.

Key word: CRP, Serum protein, urine protein, DM, CRF