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Abstract The association of high risk types Human papilloma virus(HR-HPV) with cervical intraepithelial neoplasia (CIN) and carcinoma are well known.P16INK4a, a tumour suppressor protein suggested to be a surrogate marker forHR-HPV induced cervical neoplastic changes. To study was done to assess the expression status of p16INK4a marker in CIN and cervical carcinoma. A study of 40 cases included cervical biopsies of cervical intraepithelial neoplasia and carcinoma. Immunohistochemical study of these cases were done usingp16INK4a marker.The intensity of staining and percentage of p16INK4a positive cells were observed. The study of 40 cases included 28 cases of squamous cell carcinoma (70%), one case of adenocarcinoma (2.5%), five cases of CIN (12.5%) and other three cases were non-neoplastic lesions (7.5%). One case each of CIN2 and CIN 3 were p16INK4amarker positive (2+). Among the 28 cases of squamous cell carcinoma majority showed 3+ positivity (>75% positive cells). One case of adenocarcinoma in the study showed positivity. The strong association between p16INK4a and cervical carcinoma (squamous cell carcinoma) supports the predictive role of p16INK4a study in supplement to the biopsy study for cases of CIN.

Key words: Human papilloma virus, p16INK4a, Cervical intraepithelial neoplasia, Cervical carcinoma.


STATPERSON PUBLISHING GROUP | Aurangabad | Maharashtra |2016 | INDIA
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