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Abstract  Objective: Assessing the morbidity, mortality pattern and co-relations between neonatal survival and different interventions in high risk pregnancies. Design: Case control study. Setting: Department of Paediatrics, Neonatology unit and Maternity ward tertiary care centre. Method: A 150 cases [pregnant mother with one or more medical and/or obstetrics risk factors] and 300 controls [Normal term pregnant mother] were randomly selected as study subject over a period of one year. The events were witnessed and assessed for acute life threatening events in neonates such as birth asphyxia, respiratory distress, hypothermia, hypoglycemia, neonatal convulsion, septicemia and cyanosis. Eligible neonates were received interventions in form of oxygen, bag and mask ventilation, intubation, glucose, warmth, antibiotics, phototherapy and anticonvulsant. Still birth and early neonatal death were considered as perinatal deaths. Results: Perinatal mortality rate was 54 per 1000 live births in case group whiles none in control group. A 29.25% babies develops acute life threatening events in case group as compared to 1.67% in control group [OR (23.71), 95%CI (9.01-78.13), P<0.00001]. Prematurity, low birth weight and birth asphyxia were the main causes of mortality. Conclusion: The study concludes the strategy to reduce perinatal deaths must be aimed at reducing still birth, incidence of low birth weight and premature babies by providing optimum antepartum and intrapartum care to high risk mothers and timely interventions for acute life threatening events.

Keywords: Acute Life Threatening Events, Early neonatal mortality, low birth weight, perinatal mortality rate, still birth rate



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