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Abstract          Introduction: Diabetes mellitus is the commonest metabolic abnormality in the world. Prevalence of type 2 diabetes is especially increasing in developing countries. The metabolic syndrome (Syndrome X) consists of a constellation of metabolic abnormalities that increase the risk of micro and macrovascular complications of type 2 diabetes mellitus. The major features of metabolic syndrome include central obesity, hypertriglyceridemia, low HDL cholesterol, hyperglycaemia, and hypertension. The metabolic dysregulation associated with diabetes mellitus and metabolic syndrome cause secondary pathophysiologic changes in multiple organ system that impose a tremendous burden on the individual with diabetes and on the health care system. Material and Methods: - 100 Patients of age group 20-60 years with newly diagnosed type 2 diabetes mellitus were included in the study. Detailed physical and anthropometric examinations were done in all patients. Estimation of extended lipid profile including Apo B, KFT and microalbuminuria were done. Results: Of the 100 patients studied, 58 patients had metabolic syndrome according to the International Diabetes Federation criteria 2006. 85% of the patients with metabolic syndrome were either overweight or obese (calculated by their body mass index) as compared to 15% of patients without metabolic syndrome. Waist hip ratio was increased in 33% of males with metabolic syndrome and 100% of females with metabolic syndrome. Serum triglyceride (p< 0.009), VLDLc (p< 0.007) and microalbuminuria (p< 0.01) levels were significantly elevated in patients of metabolic syndrome as compared to those without metabolic syndrome. Conclusion: The present study shows that metabolic syndrome is increasingly present in patients with type 2 diabetes mellitus in the Kumaun region of Uttarakhand. Physicians treating type 2 diabetics should consider metabolic syndrome with greater emphasis in their patients and advice early intervention, to delay the development of micro and macrovascular complications of diabetes mellitus.

Keywords: Diabetes, Metabolic syndrome.


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