Abstract      Introduction: Appendageal tumors (ATs) are neoplasms which differentiate toward or arise from pilosebaceous apparatus, apocrine gland or eccrine sweat gland. Head–neck region is unique because of its rich distribution of pilosebaceous apparatus, apocrine as well as eccrine sweat glands. Aims and Objectives: To study Clinico - Pathological Study of Patients of Skin Cancers at Tertiary health care Centre. Material and Methods: The present study of 50 cases of malignant neoplasia of skin, was carried out in the department of surgery, S.R.T.R. Medical College and Hospital, Ambajogai during the period from Jan. 1994 to Dec. 1996 respectively and prospectively. Histopathological confirmation of diagnosis was done. Histopathological examination of lymph nodes whenever thought to be clinically metastasized was carried out. Result: The age group 30 to 70 age group is more vulnerable for malignant of skin, For squamous cell carcinoma lowest age reported was 18 years and highest age was 70 years. In males, squamous cell carcinoma was the commonest neoplasm comprising of 24 (80%) cases followed by basal cell carcinoma 11 (91.66%) cases and malignant melanoma 6 (75%) cases. In females, also squamous cell carcinoma wad the commonest neoplasms comprising of 6 (66%) cases followed by malignant melanoma 2 (22%) cases followed by basal cell carcinoma 1 (11.11%) case. skin tumours were common in those patients who were exposed more to sunrays 35 (70%) cases rather than those who were less exposed to sunrays 15(30%) cases. Malignant tumours of skin were common in brown coloured patients 27(54.00%) followed by black coloured 19 (38.00%) followed by fair coloured 4 (8%) caseshistological grading of squamous cell carcinoma Grade I: Lesions have fewer than 25% undifferentiated cell Grade II: Lesions have about 50% undifferentiated cell Grade III: Lesions have about 75% undifferentiated cells. Grade IV: Lesions have more than 75% undifferentiated cells. 17 (56.66%) cases showed grade II findings on histology followed by 13 (43.33%) cases of grade I histology. Basal cell carcinoma 7 (58.33%) cases reported nodular type and 5 (41.6%) cases reported as a ulcerative type. 8 (66.66%) cases showed moderate lymphocytic stromal response. 2 (16.66%) cases showed sparse and good lymphocytic stromal response. Malignant melanoma was common in present series 4 (50%) cases followed by spindle and polyhedral 2 (25%) cases eachstromal response in malignant melanoma according to type of lesions. 2 (25%) cases presented with nodular lesion and 6(75%) cases presented with nodulo ulcerative lesion. 5 (62.5%) cases showed sparse stromal response and 3 (37.5%) cases showed moderate stromal response. Conclusion: From our study it can be concluded that The age group 30 to 70 age group is more vulnerable for malignant of skinIn males and In females squamous cell carcinoma wad the commonest neoplasms,  skin tumours were common in those patients who were exposed more to sunrays Malignant tumours of skin were common in brown coloured patients followed by black colouredhistological grading of squamous cell carcinoma Grade I: Lesions have fewer than 25% undifferentiated cell Grade II: Lesions have about 50% undifferentiated cell Grade III: Lesions have about 75% undifferentiated cells. Grade IV: Lesions have more than 75% undifferentiated cells.