Abstract     Introduction: Infertility is defined as the failure of a couple to achieve a pregnancy despite one year of regular unprotected sexual intercourse. Infertility is a global health issue, affecting approximately 8-10% of couples, worldwide¹ The 1981 census of India estimated infertility to be in range of 4 to 6%. Aims and Objectives: To Study of thyroid Hormones in the Patients of infertility. Material and Methods: The present study was conducted in the Department of Obstetrics and Gynaecology, SMGS Hospital, Government Medical College, Jammu for a period of one year. Study Group: Fifty (50) cases of infertile women, in the age group of 20 to 35 years, were selected from outpatient department and indoor. Control Group: Fifty (50) cases of non-pregnant women with proven fertility, in the age group of 20 to 35 years, were selected for control group For the continuous variable, student 't'-test (unpaired) was applied and to see for the association among the variables, chi-square test was used Result: Mean fT₃ in study group was 2.98 ± 0.64 pg/ml, while in control group it was 3.38 ± 0.64 pg/ml. The relationship between the two was statistically highly significant (p = 0.002). Mean fT₄ in study group was 1.10 ± 0.25 ng/dl, while in control group it was 1.06 ± 0.32 ng/dl. The relationship between the two was statistically not significant (p = 0.644).Mean TSH in study group was 3.93 ± 2.93 IU/ml, while in control gorup it was 2.56 ± 1.19 IU/ml. The relationship between the two was statistically highly significant (p = 0.002). Subclinical hypothyroidism was present in 11 (22%) cases, clinical hypothyroidism was present in 2 (4%) cases and subclinical hyperthyroidism was present in 1 (2%) cases in study group . In control group, only subclinical hypothyroidism was present in 2 (4%) cases. Conclusion: The study revealed that incidence of thyroid dysfunction was statistically high in infertile women as compared to parous controls, so thyroid factor should be kept in mind during diagnostic and therapeutic management of infertile women.

Keywords: Thyroid Hormones, Infertility, TSH, Free T₃ (fT₃), Free T₄ (fT₄).