Introduction: Direct laryngoscopy and endotracheal intubation is an integral part of anaesthesia which offers tremendous safety to administration of general anaesthesia but is associated with hemodynamic changes, due to reflex sympathetic discharge caused by epipharyngeal and laryngopharyngeal stimulation. Aims and Objectives: Tostudy the effect of two different doses of Gabapentin in attenuating the cardiovascular response to direct laryngoscopy and intubation. Materials and methods: Prospective, randomized, double blind and placebo controlled clinical study involving90 patients of kidwai memorial institute of oncology,Banglore visiting pre anaesthesia clinic scheduled for elective surgery under GA with ASA I and ASA II was designed after approval from institute ethics committee. Statistical analysis was done by Analysis of variance (ANOVA) to find the significance of study.Student t test (paired) has been used to find the significance within the same group. Result: Laryngoscopy and intubation caused a significant increase in heart rate and blood pressure in controlled group. Gabapentin can be used to attenuate pressor response to laryngoscopy and intubation. Gabapentin 800mg and 400mg attenuated the pressor response to laryngoscopy and intubation. SBP, DBP, MAP and HR were all attenuated by Gabapentin in comparison to control group. Gabapentin 800mg is more effective than 400mg for attenuation of pressor response to laryngoscopy and intubation (Statistically significant p<0.05) Conclusion: SBP, DBP, MAP and HR were all attenuated by Gabapentin in comparison to control group. Gabapentin 800mg is more effective than 400mg for attenuation of pressor response to laryngoscopy and intubation.

Key Words: Gabapentin, cardiovascular response to direct laryngoscopy and intubation.