Abstract     Introduction: Worldwide, diabetic foot lesions are a major medical, social, and economic problem and are the leading cause of hospitalization for patients with diabetes. Infectious agents are associated with amputation of the infected foot if not treated promptly. Materials and Methods: The present study was carried out in 56 known diabetic patients with foot ulcers attending both IPD and OPD over the period of one year at tertiary health care center. A direct Gram stained smear of the specimen was examined. Result: The majority of the patients were in the age group of Above 40 Were 25.00% followed by 36-40-23.21%;31-35-14.28%; 26-30-12.50%; 21-25-7.14%;15-20-5.35%Majority of the Patients were Males i.e. 51.78% followed by Females 48.21%. Etiologically Staphylococcus aureus- 20 (35.71%) followed by Pseudomonas aeruginosa-18(32.14%); Escherichia coli-10 (17.85%); Proteus vulgaris-4 (7.14%); Enterococcus faecium-2 (3.57%) Klebsiella pneumonia-2 (3.57%) The Most Common organism producing MRSA was Staphylococcus i.e. (77.78%) as compared to Enterococcus faecium-2 (22.22%) and Most common ESBL was Pseudomonas aeruginosa (63.63%) followed by Escherichia coli (27.27%); Klebsiella pneumonia-(4.54%); Proteus vulgaris-(4.54%). Conclusion: The majority of the patients were in the age group of Above 40, Majority of the Patients were Males, Etiologically Staphylococcus aureus. The Most Common organism producing MRSA was Staphylococcus Most common ESBL was Pseudomonas aeruginosa