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Abstract     Introduction: Most antipsychotic and antidepressant drugs like Duloxetine, Olanzepine and Resperidone etc. are known to cause hyperprolactinemia by acting on Dopamine D2 receptors in the hypothalamus and pituitary gland. Antiepileptic drugs like Valporic acid act on GABA receptors and are known to induce PCOS-like symptoms. Out of various symptoms of hyperprolactinemia – delayed menstrual cycle and galactorrheoa are significant in women patients. Aims and Objectives: To study the association of delayed menses and galactorrhoea in women takes antipsychotic, antidepressant and antiepileptic drugs in 120 women attending tertiary health care center. Methodology: In a random study where woman from 18 yrs. to 40 yrs. age group on antipsychotic, antidepressant and antiepileptic drugs are studied having complaints of delayed menstrual cycles. Patients were examined for galactorrhoea which was present in significant number of them. Serum Prolactin levels done in all patients, which were found to be raised in significant number of patients. Result: There is a clear association between certain antipsychotic, antidepressant and antiepileptic drugs causing menstrual irregularities and galactorrhoea. Hence should be prescribed with caution.

Keywords: Menstrual irregularities, Galactorrhoea, antipsychotic drugs, antiepileptic drugs, antidepressant drugs.



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