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Abstract     Background: High blood pressure has been associated with elevated atherogenic blood lipid fractions. A better understanding of the relation between blood pressure and blood lipids may provide insight into the mechanisms where by hypertension is associated with increased risk of coronary heart disease. Methods: The serum lipid profiles of 100 hypertensive patients was studied and compared with those of healthy controls. The serum lipid profiles were studied with respect to various clinical profiles like age, sex, type, incidence etc. Results: Higher number of patients with hypertension were elderly in the age group of 50-69 years. The Serum values of Total Cholesterol (TC), Very Low Density Lipoprotein (VLDL), Low Density Lipoprotein (LDL), Total Cholesterol (TC)/High Density Lipoprotein (HDL), Triglycerides (TGL), Low Density Lipoprotein (LDL)/High Density Lipoprotein(HDL) were significantly elevated in hypertensive group as compared to healthy controls. The LDL, TC/ HDL and LDL /HDL were also raised in obese patients which is statistically significant. TC/HDL and LDL/HDL were raised in Cerebrovascularaccident (CVA) group compared to non-CVA group, which is statistically very significant. The Incidence of Hyperlipidemia was more in females and majority of patients belong to type-IIa Hyperlipidemia. Interpretation and Conclusion: There was a significant alteration of lipid profile in hypertensive patients as compared to controls. Total cholesterol, LDL cholesterol, triglycerides, VLDL, TC/HDL and LDL/HDL ratios were significantly elevated in patients with hypertension. Hyperlipidemia was seen in majority of cases of hypertension with Type IIa pattern being the most frequent. Mean TC, LDL, TC /HDL, LDL/HDL were higher in obese. Mean TC, LDL, TC/ HDL and LDL/HDL ration were raised in CVA group.

Keywords: Cerebrovascular accident, Hypertension, Lipoprotein, Obesity.



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