Abstract     Introduction: Coronary Artery Disease (CAD) is an increasingly common disorder. Apart from being one of the leading causes of morbidity and mortality, it exerts a significant burden on health care expenditure .It represents a rapidly growing therapeutic challenge for health care providers. Aims and Objectives: Evaluation of prescription pattern in patients with coronary artery disease in a tertiary care centre. Materials and Methods: This prospective, observational study of prescription pattern in patients with coronary artery disease was conducted in the Department of Cardiology, Kannur Medical College, Anjarakandy. Study period was from November 2014 to January 2015 during which 200 patients, who fulfilled the inclusion and exclusion criteria were taken into study. Results: With 61% of patients being male, most of the patients were in age group 41-70 year s (76.5%).Most commonly prescribed drugs were antiplatelets (99%), antihyperlipidemic drugs (92%), antihypertensives (56%), anticoagulants (61.5%), diuretics (61%) and bronchodilators (17%). Conclusion: Polypharmacy was evident with 8.4 drugs per prescription. Improvement in prescription pattern could be achieved by reducing the number of drugs per prescription.

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