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Abstract      Lymph nodes draining tumour are considered anatomic barriers to tumour spread. The involvement of lymph nodes by metastatic spread of tumours signifies the start of a new phase in the progress of a cancer. Lymph node status is one of the most important indicators of clinical outcome. Lymph nodes are also the site where specific immune interactions between tumour antigens and lymphoid cells take place. Enlargement of nodes may be caused by spread of cancer cells or due to reactive hyperplasia of lymph nodes in response to tumour-associated antigens. The various lymphoid cell populations react in various ways, giving rise to different morphologic patterns. The current study is carried out to observe the morphological changes occurring in the regional lymph nodes and to evaluate whether these features could be helpful in assessing the immunological status of the patient and thereby, the prognosis of the patient. In this study, it was found that lymph node reaction pattern and percentage of lymph node replacement by metastatic tumour in positive lymph nodes, as well as the tumour size and reaction pattern in negative lymph nodes and the reaction pattern in negative lymph nodes and MLN ratio showed an association that was found to be statistically significant. More extensive studies on lymph node immune response patterns will be helpful in providing information on patient prognosis.

Keywords: carcinoma, colorectal, lymph nodes, reactive.


STATPERSON PUBLISHING GROUP | Aurangabad | Maharashtra |2016 | INDIA
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