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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 4, Issue 3, 2012 pp 130-133

Research Article

Correlation of Alpha-1 Antitrypsin and Smoking in Chronic Obstructive Lung Disease: An Observational Study

Deore Deepmala¹, Yogesh B. Gavali², Zingade Urjita³, Badaam Khaled⁴

¹Assistant Professor, Dept. of Physiology, Government Dental College, Aurangabad (MS) INDIA.

²Assistant Professor, Dept. of Physiology, Sree Narayana Institute of Medical Sciences, Chalakka, Ernakulam, Kerala, INDIA.

³Professor & Head, Dept. of Physiology, B.J. Medical College, Pune (MS) INDIA.

⁴Assistant Professor, Department of Physiology, Government Medical College, Aurangabad (MS) INDIA.

Abstract: Setting- The present study was carried out in the Department of Physiology, Biochemistry & Medicine Govt. Medical College, Aurangabad, Maharashtra, India. Objective- To correlate serum AAT levels in smoker and non smoker COPD patients with controls. Design- An observational study carried out in 314 subjects in the age group 40-70 years from medicine department of our college divided into three groups. Group 1- Normal healthy individuals without history of smoking (controls).Group 2- Patients with COPD for 5 years or more without history of smoking in present or past. Group 3- Patients with COPD for 5 years or more with history of smoking of at least 10 pack years. Pulmonary function tests were used for COPD diagnosis as per GOLD criteria and Serum AAT levels done by turbidimetric method. Analysis was done by ANOVA, Pearson’s correlation coefficient and Tukey’s test. Results- The results indicate that serum AAT levels were decreased in non smoker COPD patients (187.7 ± 55.42) & smoker COPD patients (133.37 ±19.36) when   compared to controls (251.5 ± 47.73). Smoker COPD patients show lowest values of serum AAT. Conclusion- So serum AAT levels can act as predictor for future development of COPD in smokers & in non smokers.