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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 5, Issue 1, 2012 pp 43-48

Research Article

Allopurinol in Inflammatory Arthritis (probably Gout): Indian Perspective in Light of EULAR Recommendations

Amit R Burande1*,Amit Kale2,Meeta A Burande3,Nitin Deshpande4

{1Associate Professor, 3Assistant Professor} D Y Patil University, Kolhapur, Maharashtra, INDIA.

2Assistant Professor, B J Medical College, Pune, Maharashtra, INDIA.

4Consulting Orthopedic Surgeon, DOH, Kolhapur, Maharashtra, INDIA.

Academic Editor:  Dr. Aher K. R.


Introduction-Hyperuricemia (solubility point of Mono Sodium Urate Crystal i.e. 7.1 mg/dl) is associated with gout and present in 0.2 to 2% of Indian popultion. EULAR has published the guidelines for the diagnosis of gout based on evidences. In this study, we tried to evaluate clinical correlation of arthralgia with serum uric acid level in Indian patients and benefit from Allopurinol treatment. Material and Methods-Study design - Prospective, open labeled single arm Study carried out in Hospital attached to Medical University. Exclusion Criteria were Patients having definitive diagnosis for the etiology of arthralgia or Definitive Gout by clinical diagnosis as per EULAR recommendation. Inclusion criteria were Patients having the history of use of analgesic with persistent symptoms, having less than 4 EULAR criteria for gout and willing to be enrolled in the study. Intervention - Allopurinol 100 mg twice a day was given to patients and clinically assessed on day 1, day 10 and at 4 week

Sample size: 28 patients were included in the study and follow up.

Results – In elderly age group incidence is same in both sexes. Purine rich diet increases the risk five times with more risk of precipitation of symptoms at lower level of uric acid. Most common site of presentation was knee pain i.e. 50%. Serum Uric acid at enrollment was 6.76+0.99 that reduced to 3.74+0.63 at four week with dissolving of symptoms. Conclusion–There is a subset of Gout in elderly Indians, which is more prone to precipitation of symptoms at lower level of serum Uric acid and equal gender distribution. Hyperuricemia in patients may be defined on 5.0 mg% and target level should be kept less than 4.0 mg in Indians.