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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 5, Issue 3, 2013 pp 121-126
Study of the Serum Superoxide Dismutase Levels in Smoking and Non-Smoking Patients with COPD
Yogesh Gavali1*, Deepmala Deore2, S. P. Surwase3, Urjita Zingade4
1Assistant Professor, Dept. of Physiology, Sree Narayana Institute of Medical Sciences, Chalakka, Ernakulam, Kerala, INDIA.
2Assistant Professor, Dept. of Physiology, Government Dental College, Aurangabad, Maharashtra, INDIA.
3Associate Professor, Dept. of Physiology, Government Medical College, Aurangabad, Maharashtra, INDIA.
4 Professor and Head, Dept. of Physiology, B. J. Medical College, Pune, Maharashtra, INDIA.
Academic Editor : Dr. Aher K.R.
Setting- The present study was carried out in the department of Physiology in collaboration with department of Biochemistry and Medicine, Govt. Medical College and Hospital, Aurangabad, Maharashtra, India. Objectives- To compare the serum superoxide dismutase (SOD) levels among healthy smokers, smoking patients with COPD and non-smoking patients with COPD and to correlate serum SOD levels with the severity of obstruction in COPD patients. Design- A total of 120 subjects in the age group of 40-70 years from medicine department of the hospital were included and they were divided into four groups.
Group: 1 - Healthy non-smoking individuals as control.
Group: 2 - Healthy smokers.
Group: 3 - Non-smoking patients with COPD.
Group: 4 – Smoking patients with COPD.
Pulmonary function tests (PFTs) were used for COPD diagnosis as per GOLD criteria and Serum SOD levels were measured by the method devised by Marklund S, Marklund G modified by Nandi and Chatterjee. The analysis of the study was done by using ANOVA, Pearson’s correlation coefficient and Unpaired t test. Results- The serum SOD levels were significantly decreased in healthy smokers (2.50 ± 0.45 U/ml), non-smoking patients with COPD (2.36 ± 0.49 U/ml) & smoking patients with COPD (2.23 ± 0.43 U/ml) when compared to controls (3.01 ± 0.23 U/ml). Also, serum SOD levels were positively correlated with FEV1% predicted in smoking and non-smoking patients with COPD. Conclusion- These results provide enough evidence of increased oxidative stress and a compromised antioxidant defence system in smokers and in patients with COPD. This study also revealed that the serum SOD levels can act as an indicator of severity of COPD, which may help in prognosis and follow-up of the treatment of patients with COPD.