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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 7, Issue 1, May 2013 pp 49-51

Research Article

Cytomorphology of Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease): A Report of Two Cases


Shruti Dogra**, Oneal Gupta*, Sharma Uma***, Gupta Kusum***

{*Senior Resident,***Professor} Department of Pathology, Vardhaman Mahavir Medical College, Safdarjung Hospital, New Delhi, INDIA.

**Assistant Professor, Department of Pathology, SGT Medical college,Hospital & Research Institute, Gurgaon, Haryana, INDIA.


Academic Editor : Dr. Aher K.R.



Rosai–Dorfman disease (RDD), a rare, benign, self-limiting histiocytic proliferative disorder, can be encountered in both nodal and extranodal locations, and fine needle aspiration (FNA), a simple, accurate and economic tool, has been widely used for the diagnosis of superficial and deep-seated lesions. Familiarity with the cytomorphologic features of RDD is important as prognosis and treatment are quite different from other benign or malignant diseases for which it may clinically masquerade. We report two cases of Rosai–Dorfman disease, one with typical and other with an unusual cytomorphological feature. Pathologist should be aware of the variations in the cytomorphological features of RDD so that a correct diagnosis is not missed on FNAC. We  concluded that FNAC is a useful and reliable tool for the diagnosis of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and biopsy can be avoided in these patients, thereby reducing patient inconvenience and health care cost.