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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 7, Issue 3, July 2013 pp 129-131

Research Article

Association of Hyperuricemia and Osteoarthritis Knee in Costal Indian Population

Challa Supradeeptha¹, Sudhir M. Shandilya², Alavalapati Naresh³, Satyaprasad J.⁴

Academic Editor : Dr. Aher K.R.

Objectives: previous studies have shown an association between serum uric acid and generalized osteoarthritis, but with the limited studies on evidence of association between serum uric acid and knee joint osteoarthritis. This study is to know the association between serum uric acid levels and osteoarthritis of knee joint. Methods: This is a prospective study including two hundred and seventy five patients (186 males, 89 females) with clinically diagnosed osteoarthritis of knee. Their serum uric acid level, Rheumatoid factor, standing radiographs of affected knees and hands were obtained. The presence of radiographic osteoarthritis of the knee was analyzed using Keligren-Lawrence system. Patients were divided into three groups basing on serum uric acid levels. Group 1: - serum uric acid less than 4mg/dl, Group 2: - serum uric acid levels between 4.1-7 mg/dl, Group 3: - serum uric acid levels more than 7 mg/dl. Results: Isolated knee joint osteoarthritis is present in 187 patients (68 %), generalized osteoarthritis is seen in 54 (19.6 %) patients, and Rheumatoid Factor, along with C-reactive protein is positive in 34 patients. There is a significant positive association present between isolated knee joint osteoarthritis, generalized osteoarthritis and the highest tertile of serum uric acid [adjusted odd’s ratio- 2.25, 95% confidence interval- l.58-2.95 and adjusted odd’s ratio- 3.27, 95% confidence interval- 2.85-4.02 respectively). There is a significant positive association between high serum uric acid levels and progression of the knee joint osteoarthritis (highest tertile versus lowest tertile of serum uric acid odd’s ratio- 2.03, 95% confidence interval-1.02-3.76). Conclusion: It is concluded that knee joint osteoarthritis, generalized osteoarthritis and there progression are associated with hyperuricemia.