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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 8, Issue 1, August 2013 pp 04-08

Research Article

A Study of Efficacy of Misoprostol in Early Pregnancy Loss


R. P. Patange1, Dileep P. Javadekar2, Archana Rokade3

(1Professor & HOD, 2,3Assistant Professor) Department of OBGY. KIMSDU, Malkapur Maharashtra, INDIA.



Academic Editor : Dr. Aher K.R.



This study aims to assess the efficacy of misoprostol in the management of missed miscarriage and anembryonic pregnancy. Data of 123 consecutive women with early pregnancy loss treated with medical method were collected prospectively in rural medical college hospital. Each woman received 600µg of misoprostol vaginally. Three hours following the first dose second dose was given if necessary. Women that failed to pass products of conception or had incomplete abortion on ultrasound scan were offered surgical evacuation. Success was defined as complete uterine evacuation within 12 hours on ultrasound scan, without need for surgical evacuation. Results: The overall success rate of medical management was 89.43%.the median dose of misoprostol required was 1200µg.and the median induction miscarriage interval after first dose of Misoprostal was 7.1±3.5 hours (range 6-10hrs) In 13 women medical method failed. Side effects were less common and mild.