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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 8, Issue 1, August 2013 pp 12-15
Research Article
Thyroid Hormone Status of Normal Pregnant Women
Swati Tadas1, Arun Tadas2, Nilam Mishra3, Aniruddha Jibhkate4
{1,4Assistant Professor, 3Professor, Department of Physiology} {2Associate Professor, Department of Biochemistry}
Government Medical College and Hospital, Nagpur, Maharashtra, INDIA.
Academic Editor : Dr. Aher K.R.
Objectives: To study thyroid hormone status of normal pregnant women in each trimester and compare it with non-pregnant women. Materials and Methods: This was a longitudinal type of study. Serum levels of T3, T4 and TSH were estimated by ELISA technique in normal pregnant women (n=60) in each trimester and compared with age matched control (n=60). Results: We found significant increase in T3 and T4 level in 1st trimester (P<0.01) when compared to control group. In 2nd trimester values increased further (P<0.01) and in 3rd trimester increase was statistically highly significant (P<0.001). We observed decreased TSH level in 1st trimester (P<0.01) when compared to control group. In 2nd trimester values increased further but difference was not statistically significant (P>0.05). In 3rd trimester there was statistically significant rise in values when compared to control group. Conclusion: Interpretation of thyroid function test in pregnancy needs care and separate reference intervals should be used.
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