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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 8, Issue 2, August 2013 pp 106-108

Research Article

Hyperprolactinemia and Its Comparison with Hypothyroidism in Infertile Women


Shamali Jungare1, Seema Vaidya2

1Assistant Professor, Department of Biochemistry, Government Medical College and Hospital, Akola, Maharashtra, INDIA.

2Ex. Professor, Department of Biochemistry, Government Medical College and Hospital, Nagpur, Maharashtra, INDIA.

Academic Editor : Dr. Aher K.R.


Infertility is a growing problem among women. Hyperprolactinemia is one of the important factors in pathogenesis of anovulation, amenorrhea galactorrhea syndrome and other menstrual disorders. Hypothyroidism may also cause failure to ovulation in women of reproductive age group. Thus this study has been conducted to correlate prolactin and thyroid stimulating hormone (TSH) levels in infertility. Two groups of women comprising of 50 infertile cases as study group and 50 with normal fertility female controls were thoroughly examined and subjected to investigation for prolactin and thyroid factor. The serum levels of hormones prolactin and TSH were measured by using ELISA method.  We found that the serum prolactin in infertile group (67.90±20.05ng/ml) was found to be high as compared to the control group (11.60±5.19ng/ml) with incidence of hyperprolactinemia in infertility was found to be 38%. The incidence of hypothyroidism in infertility was found to be 18% , with mean serum TSH to be significantly increased in infertile group (10.25±5.21mlU/ml) as compared to control (2.5±0.61mlU/ml). Thus our study showed that there is high incidence of hyperprolactinemia in infertile women as well high increased incidence of hypothyroidism in these women emphasizes importance of screening of prolactin and TSH levels in these women.