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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 8, Issue 2, August 2013 pp 134-137

Research Article

Screening of Antibacterial and Antifungal Activity of Gandhaka Rasayana- an Ayurvedic Formulation

 Reshma M. Saokar¹, R. S. Sarashetti², Veena Kanthi³, Madhav Savkar⁴, C. V. Nagthan⁵

¹Assistant professor, Department of Rasashastra and BK, SDM College of Ayurveda, Hassan, Karnataka, INDIA.

²Professor cum Project officer, BLDEAs, Ayurveda Mahavidyalaya Bijapur, Karnataka, INDIA.

³Professor, Late Kedari Redekar Ayurvedic College, Gadinglaj, Kolhapur, Maharashtra, INDIA.

⁴Prof. Department of Pharmacology, AIMS, Banglore, Karnataka INDIA.

Academic Editor : Dr. Aher K.R.

Introduction: Antimicrobial agents are commonly used nowadays for treating various bacterial and fungal infections. But still most of the physicians are unable to treat these infections appropriately due to hindrances like development of resistance, adverse effects, patient affordability etc. Gandhaka Rasayana formulation mentioned in Ayurvedic Texts can be an ideal replacement for treating various infectious diseases. Assessment of its antibacterial and antifungal activity may provide scientific evidence for the study. Method: Gandhaka Rasayana prepared with classical reference was subjected for analysis and invitro antibacterial and antifungal activity by cup plate method. Different concentrations of the drug was tested against bacteria like Staphylococcus aureus, Pseudomonas auregenosa and E coli and fungi Aspergillus niger, Cryptococcus neoformans, Candida albicans and Trycophytum rubrum taking Fluconazole as standard for comparison. Results: Gandhaka Rasayana solutions in different concentrations showed a significant zone of inhibition against three strains of bacteria (22-30mm) and four strains of fungi (16-25mm) when compared to Fluconazole (22mm) and control. As Gandhaka Rasayana contains Fe (433.84), Cu (32.77), Ni (10.32) Zn (10.32), Ca (0.84%), Na (0.17%), As (12.14), triclinic cells, carbohydrates, steroids and tannins it may contribute to promote positive health and vigour by increasing the immunity, thus making the body resistant against disease causing factors.   Conclusion: Gandhaka Rasayana showed a significant antibacterial and antifungal activity, but antibacterial activity was significant compared to antifungal activity.