 |
[Abstract] [PDF] [HTML] [Linked
References]
International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 8, Issue 2, August 2013 pp 138-142
Research Article
Effect of Lamotrigine on Dopamine Dependent Behaviours in Rats
Shinde A. R.1, Shinde R. V.2*, Thorat V. M.3, Jadhav S. A.4, Balsara J. J.5
{1Assistant Professor, 3Professor, 4Associate Professor, 5Ex. Professor and HOD, Department of Pharmacology}
{2Assistant Professor, Department of Microbiology}
KIMS, Karad, Maharashtra, INDIA.
Academic Editor : Dr. Aher K.R.
Lamotrigine is an antiepileptic drug which by inhibiting voltage dependent sodium channels inhibits release of glutamate. Thus Dopaminergic system is removed from inhibitory influence of glutamate, causing increase in levels of dopamine in striatum resulting in stereotyped behavior (SB) or abolition of catalepsy in animals. Objectives of our study were to study the effect of Lamotrigine (LTG)on dopamine dependent behaviours in rats and compare its intensity with effects produced by Dexamphetamine (DAM) and Apomorphine (APO), to study the effect of pretreatment of HAL on SB induced by LTG. and to study effect of LTG on catalepsy induced by HAL. We also did similar pretreatments with APO and DAM which we have used as reference drugs. We used albino rats of either sex (120-180 g) by random distribution in group of 10 animals each. Intensity of SB and catalepsy is assessed by Costall and Naylor scoring system. Our results indicate that, LTG produced (SB) at 5,10,20 and 40 mg/kg .Which is less in intensity than 1.5 , 3mg/kg of APO and 5 , 10 mg/kg of DAM. This SB was abolished by HAL at 0.25 and 0.50 mg/kg, therefore we state that Lamotrigine produces SB by releasing dopamine and on weight basis LTG is less potent in antagonizing haloperidol induced catalepsy as compared to DAM and APO.
|
