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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 8, Issue 3, October 2013 pp 200-202

Research Article

Histogenesis of Endodermal Component of Human Fetal Thymus


Bashir Khan1, Vinaram Rukhmode2, Sanobar Shaikh3, Chhaya Diwan4

1Assistant Professor, 2Professor and HOD, Department of Anatomy, Shri Bhausaheb Hire Government Medical College, Dhule, Maharashtra, INDIA.

3Associate Professor, 4Professor, Department of Anatomy, Government Medical College, Aurangabad, Maharashtra, INDIA.

Academic Editor : Dr. Aher K.R.


The present study is conducted to observe the early cellular events and histological maturity endodermal component of thymus. After ethical approval from institutional ethics committee 53 human fetuses were obtained from department of Obstetrics and Gynaecology with permission of head of department and written informed consent from respective parents. The gestational age was determined by menstrual history and Crown Rump length (CRL). The specimen were dissected through parasternal incision and processed in paraffin. The sections were taken by rotary microtome. The slides were stained by Haematoxylin and eosin and Periodic acid-Schiff (PAS) stains. Endoderm of thymus differentiate into epithelial cells which from cytoreticulum and Hassall’s corpuscles in medulla. Epithelial cells are first observed at 10th week. Hassall’s corpuscles appeared PAS positive. They are first observed at 12th week and increased in size and number with increase in gestational age.