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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 8, Issue 3, October 2013 pp 209-211

Research Article

Comparitive Study of Blood Glucose, Glycosylated Hemoglobin, Serum Cholesterol, Triglycerides and H.D.L. Levels in Lean, Nonobese and Obese Type 2 Diabetes Mellitus

Dhananjay V. Bhale

Professor and HOD, Department of Biochemistry, MGMS Medical College Aurangabad, Maharashtra, INDIA.


Academic Editor : Dr. Aher K.R.


Background:  Diabetes has emerged as a major public health problem in our country Insulin has important effects on key steps in metabolism of lipids and lipoproteins and altered lipid metabolism is common in diabetic population. As far as diabetes in India is concerned, the vast majority are found to be nonobese. More peculiarly prevalence is rising in lean persons. Very little data is available on Nonobese type 2 diabetes and especially on those who have low body weight BMI<18.5Kg/m2 i.e. Lean type 2 Diabetes mellitus. In this study we tried to study Pecularities and differences of Lipid profile and diabetic profile in lean, nonobese and obese type 2 Diabetes mellitus in Marathwada Region. Materials and Methods: Present study was carried out in MGM Medical College, Aurangabad. Total 90 known cases of type 2 diabetes mellitus were taken from 30 to 60 years age group with  no h/o Hypertension, chronic kidney disease, stroke and acute myocardial infarction in past. They were divided into three groups as follows: Lean, Nonobese and obese. Fasting and Postprandial Blood glucose measured by glucose oxidase method on RA 1000 fully automated Biochemistry Analyser. Glycosylated Hemoglobin was estimated by Flukinger and Winterbalter’s colorimetric method. Serum Cholesterol, Triglycerides, and H.D.L. by kit method on RA 1000. Conclusion: The increase in glycosylated haemoglobin in lean diabetics as compared to nonobese and obese is statistically significant (P<0.05). This shows that Lean t type 2 diabetics had a poor glycemic control as compared to nonobese and obese type 2 diabetics. Serum cholestrol values were low in lean as compared to non obese and obese diabetics. Triglycerides were lower (P < 0.05) in lean diabetics.