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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 8, Issue 3, October 2013 pp 219-223

Research Article

Evaluation of Serum Sialic Acid and Microalbuminuria in Diabetic Nephropathy

 D. A. Divija1, A. Rajeshwari2, Aliya Nusrath3

1Tutor, Department of Biochemistry, HIMS, Hassan District, Karnataka, INDIA.

{2Associate Professor, 3Professor and HOD} Dept of Biochemistry, AIMS, Mandya District, Karnataka, INDIA.



Academic Editor : Dr. Aher K.R.


Diabetes mellitus is the most common endocrine disorder, the prevalence of which is rising alarmingly in India. Diabetic nephropathy is a major microvascular complication of diabetes mellitus and the most common cause of end stage renal disease worldwide. Serum sialic acid, an acute phase reactant and urinary albumin excretion are found to be increased in diabetic nephropathy patients. In diabetes, acute phase reactants are considered as the indicators of microvascular angiopathy. Microalbuminuria is a predictor of incipient nephropathy in diabetic patients. Hence the study was undertaken to evaluate serum sialic acid and microalbuminuria levels and to assess the correlation of serum sialic acid and microalbuminuria with glycemic control in diabetic nephropathy patients. Present study involved 100 participants of which 50 were diagnosed to have diabetic nephropathy and 50 were age and sex matched healthy controls. Blood samples were analyzed for fasting and post prandial blood sugar (FBS, PPBS), blood urea, serum creatinine, serum sialic acid, glycated hemoglobin (HbA1c) and urine sample for microalbumin levels and systolic, diastolic blood pressure was recorded in both cases and controls. Statistical analysis was done using Student’t’ test (two tailed, independent) to find the significance of study parameters on continuous scale between two groups (Inter group analysis) on metric parameters. Pearson correlation between the study variables is performed to establish the relationship. Statistically significant increase in levels of FBS, PPBS, blood urea, serum creatinine, serum sialic acid, HbA1c, systolic, diastolic blood pressure and urinary microalbumin was observed in cases  compared to controls (p<0.001). A positive correlation was found between glycemic status, serum sialic acid and urinary microalbumin levels in diabetic nephropathy patients. Elevated serum sialic acid and urinary microalbumin levels are strongly associated with the presence of nephropathy. Serum sialic acid can be used as a marker of renal dysfunction in diabetic nephropathy.