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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 8, Issue 3, October 2013 pp 163-166

Research Article

Protein carbonylation, Lipid peroxidation and serum alpha Tocopherol activity in Preeclampsia

N. Asha Rani¹, J. N. Naidu²

¹Assistant Professor, Department of Biochemistry, AIMS, BG Nagara, Mandya District, Karnataka, INDIA.

Academic Editor : Dr. Aher K.R.

Hypertensive disorders are the most common medical complication of pregnancy and are important cause of maternal and perinatal morbidity and mortality. The etiology of preeclampsia has always remained elusive. More recently, antioxidants have been proposed as a potential preventive strategy on the basis of data suggesting that endothelial dysfunction is fundamental to the development of preeclampsia as a result of increased oxidative stress and deficiency of antioxidant protection. In this context the present study was undertaken to evaluate the intensity of oxidative stress and to investigate a possible correlation between oxidative stress, antioxidant status and severity of preeclampsia. A case control study was performed on 50 normal pregnant and 50 diagnosed preeclamptic women age and trimester matched. Malondialdehyde (MDA), Protein Carbonyls (PCO)and Vitamin E(Vit E) were estimated in the serum of all subjects. Statistically significant increase in levels of PCO (p< 0.0001), MDA (p <0.0001) and decrease in Vit E (p<0.0001) were observed in preeclamptic women as compared to normal controls. A negative correlation between oxidative stress markers (MDA, PCO) and Vit E and positive correlation between oxidative stress markers (MDA, PCO) and blood pressure was observed in preeclamptic women. Increased  MDA, PCO and decreased  Vit E suggests an imbalance between the oxidative stress and antioxidant status which supports the hypothesis that the oxidative stress is an important causative factor in pathogenesis of preeclampsia and  supplementation with antioxidant vitamin may benefit the preeclamptic mothers.