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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 8, Issue 3, October 2013 pp 167-170
Research Article
Effect of Alpha-Methyl-P-Tyrosine Pretreatment on Stereotyped Behaviour Induced by Lamotrigine, Apomorphine, Dexamphetamine in Rats
Shinde A. R.1, Thorat V. M.2, Jadhav S.A.3, Balsara J. J.4, Shinde R. V.5
{1Assistant Professor, 2Professor, 3Associate Professor, 4Ex. Professor and HOD, Dept. of Pharmacology}
{5Assistant professor, Dept. of Microbiology}
KIMS, Karad, Maharashtra, INDIA.
Academic Editor : Dr. Aher K.R.
Alpha-methyl-p-tyrosine by inhibing tyrosine hydroxylase, decreases the synthesis of dopamine (DA) in the nigrostriatal DAergic neurons so less DA is available for release from these neurons. Lamotrigine(LTG), Dexamphetamine(DAM) and Apomorphine (APO) produce SB directly by stimulating DA receptors or indirectly by releasing DA from nigrostriatal DAergic neurons .Our aim is to study the effect of pretreatment of alpha methyl P tyrosine(AMT) on SB induced by LTG,DAM and APO in rats. Albino rats of either sex (120-180 g) were used by random distribution in group of 10 animals each. Intensity of SB is assessed by Costall and Naylor scoring system. Our results indicate that pretreatment with 100 mg/kg AMT significantly antagonised the SB induced by 5, 10, 20 and 40 mg/kg lamotrigine. Pretreatment with 200 mg/kg AMT abolished the SB induced by 5 mg/kg lamotrigine and significantly antagonised the SB induced by 10, 20 and 40 mg/kg lamotrigine. Pretreatment with 100 and 200 mg/kg AMT significantly antagonised the SB induced by 5 and 10 mg/kg dexamphetamine. Pretreatment with 100 and 200 mg/kg AMT did not significantly influence the intensity of SB induced by 1.5 and 3 mg/kg apomorphine.
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