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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 8, Issue 3, October 2013 pp 178-181

Research Article

Evaluation of Amiodarone for Its Effect on Glucose Metabolism in Euglycemic Albino Wistar Rats


Mohammed Sibgatullah1, Suresha R. N.2

1Tutor and PG Student, 2Professor and HOD, Department of Pharmacology, JSS Medical College, JSS University, SS Nagar, Mysore-15, Karnataka, INDIA.

Academic Editor : Dr. Aher K.R.


Objective: To evaluate the effect of amiodarone on glucose levels in albino wistar rats. Materials and Methods: Albino wistar rats were divided in to test group (amiodarone) and control group (distilled water) of six animals each. They were given test drug i.e amiodarone 180mg/kg and distilled water 5ml/ rat respectively for a period of 5 days. On 5th day OGTT (slightly modified) was performed and cbg values were recorded at 0 min, 60min and 150 min respectively. Results and Discussion: The cbg values were significantly higher (p<0.05) in test group at all the time intervals thereby indicating that amiodarone has hyperglycemic activity in the albino wistar rats. Conclusion: Further studies are required to evaluate the effect of amiodarone in humans and it should be used with caution in diabetics patients.