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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 9, Issue 1, November 2013 pp 62-65
Comparative Study of Blood Glucose and Glycosylated Hemoglobin Levels and Clinical Profile in Low Body Weight (lean), Nonobese and Obese Type 2 Diabetes Mellitus
Dhananjay V. Bhale
Professor and HOD, Department of Biochemistry, MGM Medical College, Aurangabad, Maharashtra, INDIA.
Academic Editor : Dr. Aher K.R.
Background: Diabetes has emerged as a major public health problem in our country Insulin has important effects on key steps in metabolism of lipids and lipoproteins and altered lipid metabolism is common in diabetic population. As far as diabetes in India is concerned, the vast majority are found to be nonobese. More peculiarly prevalence is rising in lean and underweight persons. Very little data is available on Nonobese type 2 diabetes and especially on those who have low body weight BMI< 18.5 Kg/m2. Materials and Methods: Present study was carried out in MGM Medical College, Aurangabad. Total 90 known cases of type 2 diabetes mellitus were taken from OPD, Medicine wards of above institute and were divided into three groups as follows: Lean (B.M.I.< 18.5) Nonobese (B.M.I.= 18.5-25) and obese( B.M.I.>25). B.M.I.(Body mass index): Weight in kg/height in m2. Following biochemical parameters were done
1. Fasting and Postprandial Blood glucose measured by glucose oxidase method on RA 1000 fully automated Biochemistry Analyser
2. Glycosylated Hemoglobin was estimated by Flukinger and Winterbalter’s colorimetric method.
Conclusion: The increase in glycosylated haemoglobin in lean i.e. Group I diabetics as compared to nonobese and obese is statistically significant (P<0.05). This shows that low body weight type 2 diabetics had a poor glycemic control as compared to nonobese and obese type 2 diabetics.