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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 1, November 2013 pp 89-95

Research Article

Comparative Study of Clinical Efficacy and Adverse Drug Reactions Produced by Enalapril and Ramipril in Patients of Moderate Hypertension


Santosh C. Gursale1, Mohankrishna Ghanta2, Narayan P. Burte3, Sudheer Kumar4

1Professor and Head Department of Pharmacology, I.M.S.R. Mayani, Satara, Maharashtra, INDIA.

3Professor and Head, 2,4MSc. P.G. Student, Department of Pharmacology, M.N.R. Medical College, Sangareddy, Andhra Pradesh, INDIA.

Academic Editor : Dr. Aher K.R.



 Introduction: Hypertension is one of the leading causes of global burden of disease. Approximately 7.6 million deaths [13-15% of total deaths] and 92 million disability-adjusted life years worldwide were attributable to high blood pressure in 2001. Angiotensin converting enzyme inhibitors (ACEIs) have a well-established role in the management of essential hypertension.This study was prompted by the fact that a large number of people suffer from essential hypertension and ACEIs certainly are among the most widely prescribed agents in its treatment. It is therefore imperative that we should have maximum data on their pattern of utilization and the adverse drug reactions.Aims and Objective- To observe and compare the anti-hypertensive efficacy as well as incidence of adverse drug reactions between enalapril and ramipril. Materials and Methods-This prospective, comparative, open-label study included 80 patients suffering from stage I / II essential hypertension. These patients included males and females randomized in each study Group. Observation and Result: In the present study, we observed that enalapril, ramiprilare effective agents in reducing both systolic and diastolic BP throughout the study period when measured at the 15thday, 30thday, 45thday and 90th day. When efficacy was compared, we found that these two drugs were equally effective in reducing the systolic and diastolic blood pressure. A total of 25% of the patients reported some sort of adverse-effects like cough (10%), nausea(7.5%), musculoskeletal pain(2.5%), headache (5%) and dizziness (0%) in the enalapril treated Group A and  22.5%in the ramipril treated Group B, with noted adverse-effects like cough(10%), headache (5%), dizziness (2.5%), nausea (5%) and musculoskeletal pain(0%). Conclusion-The antihypertensive effect of these two drugs included in the study was statistically significant.These two drugs were equally effective in reducing the systolic and diastolic blood pressure. The incidence of nausea and musculoskeletal pain was more in enalapril treated group than ramipril group and incidence of dizziness was more in ramipril group than enalapril Group. However, this difference in the frequency of overall adverse-effects between the two groups was not statistically significant (P > 0.05).  Adverse effects were tolerated by both the study Groups and hence effective antihypertensive drugs in management of essential hypertension.