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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 1, November 2013 pp 100-104

Research Article

Anticarcinogenic Effects of Garlic Aqueous Extracts in Nitroso R Salt (1-Nitroso-2-Naphthol-3,6-Disulfonic Acid Disodium Salt Hydrate) Induced Hepatoma in Rats


Kanthaiah1, Govindaswamy K. S.2,   Omprakash K. V.3

{1Department of Biochemistry, 3Department of Anatomy} Hassan Institute of Medical sciences, Hassan, Karnataka, INDIA.

2Department of Biochemistry, Shimoga Institute of Medical sciences, Shimoga, Karnataka, INDIA.

Academic Editor : Dr. Aher K.R.



Garlic has long been used as a popular remedy for many ailments since a long time .The present work was undertaken to study the anticarcinogenic and antitumorigenic effects of garlic aqueous extracts in experimentally induced hepatoma in rats as well as establish a possible anticancer mechanism of garlic. The protective effects of garlic aqueous extracts against chemical induction of hepatoma as well as the curative effects of these extracts in chemically induced hepatoma rats were studied. It is evident from the results that garlic aqueous extracts gives protection against chemical hepatoma induction. There is a considerable improvement seen in chemical induced hepatoma rats given garlic aqueous extracts. These protective as well as curative effects of garlic aqueous extracts may be due to its principal sulfur compound diallyl disulfide.The  principal organosulphur compound of garlic is known to possess many clinical beneficial effects, but  its overuse or abuse has been reported to cause certain harmful side effects due to its possible metabolite acrolein. It was thought that the disulphide nature of dially disulphide is responsible for its anticarcinogenic and antitumorigenic effects.