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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 1, November 2013 pp 109-111

Research Article

Prevalence of ESBL Production in Gram Negative Isolates in a Tertiary Care Hospital in Gulbarga


Sufia M. Siddiqui1, Imran N. Khan2, Bilal Ahmed3, P. Akther4

{1Associate Professor, Department of Microbiology} {2Professor, Department of Pharmacology} IIMSR,Warudi,Jalna, Maharashtra, INDIA.

3,4Tutor, Department of Microbiology,KBN Medical College,Gulbarga, Karnataka, INDIA.

Academic Editor : Dr. Aher K.R.



Extended Spectrum Beta lactamases are enzymes that mediate resistance to third generation Cephalosporins rendering treatment with these antibiotics ineffective. Bacterial strains that produce these enzymes pose various problems in the management of infectious diseases. With this objective in mind, a total of 272 gram negative, clinical isolates were initially screened for ESBL production, and then confirmed by CLSI confirmatory method. Of the 231 screen positive (85%) isolates, 151 (56%) were confirmed as ESBL positive. Among these, ESBL production was 72% in Klebsiella, 56% in Ecoli, 24% in Citrobacter, 29% in Proteus, 5% in Enterobacter, 15% in Pseudomonas and 33% in Acinetobacter. Considering the statistically significant production of ESBL in these isolates, routine screening of these enzymes is advised in all tertiary care hospitals.